NFL DFS, Rams vs. 49ers: Best DraftKings, FanDuel daily Fantasy football picks for Monday Night Football

The San Francisco 49ers will host the Los Angeles Rams in an NFC West rivalry game on Monday Night Football. The two teams will meet for the first time since last season’s NFC Championship Game, which means plenty of tough decisions for your NFL DFS teams. The NFL DFS player pool is filled with stars like Cooper Kupp, Matthew Stafford, Deebo Samuel and George Kittle. Success in single game slates while playing NFL DFS tournaments, cash games and 50-50s on FanDuel and DraftKings is all about spotting. Which players have the best NFL DFS picks for Rams vs. 49ers and how should you diversify your NFL DFS lineups? Before you make your NFL DFS picks for 49ers vs. Rams, be sure to check out SportsLine Fantasy Daily Expert Mike McClure’s NFL DFS tips, strategy and player projections.

McClure is a legendary professional DFS player with over $2 million in career winnings. His methodology has led to huge cash-ins on FanDuel and DraftKings. He landed two high-stakes tournaments on FanDuel in 2020 and recorded a pair of top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished in the top 1% in more than a dozen other tournaments.

It uses a powerful prediction model that simulates every snap of NFL action, taking into account factors such as matchups, statistical trends and injuries. This allows him to find the best DFS prices that he only shares with members at SportsLine.

In Week 3, McClure had Eagles quarterback Jalen Hurts as one of his top NFL DFS picks for both FanDuel and DraftKings: The result: Hurts had 340 passing yards, 20 rushing yards and three passing yards touchdown, returning 30.6 points to DraftKings and FanDuel. Whoever had him in their lineup was well on their way to a huge day.

Now, McClure has turned his attention to the Rams vs. You can only see his picks and analysis on SportsLine.

Top NFL DFS picks for Rams vs. 49ers

One of McClure’s top NFL DFS picks for Monday Night Football is 49ers wide receiver Brandon Aiyuk. After a strong rookie season, Aiyuk wasn’t heavily involved in San Francisco’s offense early in 2021, but he returned to the coaching staff and Jimmy Garoppolo’s good graces and finished the year with even better numbers than he had in 2020.

Aiyuk has played at least 88 percent of the snaps over the last 14 games and has 57 catches for 872 yards and five touchdowns during that span. He has been targeted eight times in each of the last two games and has eight catches for 102 yards and a score in those contests, despite San Francisco’s offense not reaching 200 yards in a game this season. However, the Rams rank 23rd in the NFL in pass defense, so this could be a spot for Aiyuk and the 49ers offense to spark their season.

McClure’s optimal NFL DFS strategy also features Rams receiver Cooper Kupp. Coming off a season in which he caught 145 passes for 1,947 yards and 16 touchdowns, Kupp is once again putting up impressive numbers. He has caught 28 passes for 280 yards and three touchdowns and had a 20-yard rushing touchdown last week against the Cardinals.

Kupp has been targeted 35 times through the first three weeks of the season to lead the league and also has the highest target share (34.7 percent) and snap share (98.3 percent) of any NFL receiver. He had 11 catches for 142 yards and two touchdowns in the NFC title game win over San Francisco last season and has surpassed the 100-yard mark in his last three games against the 49ers. You can see the rest of McClure’s NFL DFS tips here.

How to Build NFL DFS Lines for 49ers vs. Rams

McClure is also targeting another underrated pick who could explode for huge numbers. This pick could be the difference between winning tournaments and cash games or going home with nothing. You can see just who it is and the rest of McClure’s NFL DFS picks at SportsLine.

Who does Mike McClure include in his best NFL DFS lineups for Monday Night Football? And which under-the-radar player is a must-roster? Visit SportsLine now for the best NFL DFS picks, ratings, tips and stacks, all from a DFS expert who has won millions with his daily Fantasy picks and find out.

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