NFL Odds, Lines, Picks, Spreads, Best Bets, Predictions for Week 5, 2022: Model loving Titans, Jaguars

The reach of Cowboys nation is likely to be on full display Sunday when Dallas visits the Los Angeles Rams. Cowboys training camp is underway in Southern California, and what should be a split crowd has the Rams as a 5.5-point home favorite in the latest Week 5 NFL odds from Caesars Sportsbook. Dak Prescott won’t return after thumb surgery, leaving Cooper Rush to try to cover one of the NFL’s biggest spreads of the week.

The Cowboys are 3-1 against the spread this season, while the Rams are 1-3. The NFL’s Week 5 schedule features Cowboys vs. Rams as one of four games with Week 5 NFL Vegas lines of more than a field goal but less than a touchdown. All Week 5 NFL lines are listed below and SportsLine’s advanced computer model has all the NFL betting tips and predictions you need to make your best Week 5 NFL picks now.

The model, which simulates each NFL game 10,000 times, has cost nearly $7,000 for $100 players on top NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 streak with top NFL picks dating back to the 2017 season.

The model also ranked in NFLPickWatch’s top 10 four of the last six years in straight NFL picks and won over 94% of CBS Sports Football Pick’em players four times in that span. Anyone who has followed it is very high.

Now, she’s turned her attention to the latest Week 5 NFL odds and locked down picks for every NFL game. Head here to see each option.

Top Week 5 NFL Predictions

One of the model’s strongest picks for NFL Week 5 is that the Titans (-2.5) cover the Commanders in nearly 60% of simulations. Washington has one more win than the Houston Texans, but you can argue that the Commanders are the worst team in the league. They rank 25th in scoring offense and 29th in scoring defense, making them the only team in the bottom 10 in both categories.

Meanwhile, Tennessee has rediscovered the type that allowed them to be the AFC’s No. 1 overall seed last year. The team has won and covered its last two games, thanks to Derrick Henry reclaiming his throne as arguably the best running back in the league. Henry has rushed for over 140 yards in back-to-back weeks despite facing two top-10 defenses. Tennessee is covered as a 2.5-point favorite in nearly 60% of simulations.

Another one of her Week 5 NFL predictions: The Jaguars (-7) cover a divisional game at home against the Texans. Jacksonville has played just one home game so far, a 24-point shutout win over the Colts. Jacksonville ranks third at +38 points, trailing arguably only the top two teams in the NFL, the Bills and Eagles.

The Jags fell to Philly in Week 4 thanks to wet conditions that led to four turnovers by Trevor Lawrence. That was certainly a one-game advantage, as Lawrence had just three combined shutouts in his previous 17 games. The Jags have a top-10 offense and a top-10 defense, while Houston ranks in the bottom half of the league in both categories. Jacksonville is projected to win by double digits and cover over 50% of simulations. The model also has the Under (44.5) hitting over 50 percent of the time. See what other teams to choose from here.

How to make Week 5 NFL picks

The model has also called who wins and who covers every other game on the NFL’s Week 5 schedule, and also says an underdog causes a huge upset. You can only get every pick for every game on SportsLine.

So, which NFL picks can you make with confidence? And which underdog causes a huge upset? Check out the latest NFL odds below, then visit SportsLine to see which teams are winning and covering the spread, all from a tested computer model that has returned nearly $7,000 since its inception and find out.

Week 5 NFL Odds, Lines, Spreads

Get complete NFL picks on SportsLine

Thursday, Oct. 6

Colts at Broncos (-3, 42)

Selected game | Denver Broncos vs. Indianapolis Colts

Sunday, Oct. 9

Giants at Packers (-8, 41)

Selected game | Green Bay Packers vs. New York Giants

Steelers at Bills (-14, 46.5)

Selected game | Buffalo Bills vs. Pittsburgh Steelers

Chargers at Browns (+2.5, 47.5)

Selected game | Cleveland Browns vs. Los Angeles Chargers

Texans at Jaguars (-7, 43.5)

Selected game | Jacksonville Jaguars vs. Houston Texans

Bears at Vikings (-7, 44)

Selected game | Minnesota Vikings vs. Chicago Bears

Lions at Patriots (-3, 45.5)

Selected game | New England Patriots vs. Detroit Lions

Seahawks at Saints (-5.5, 46)

Selected game | New Orleans Saints vs. Seattle Seahawks

Dolphins at Jets (+3.5, 46)

Selected game | New York Jets vs. Miami Dolphins

Falcons at Buccaneers (-9, 48)

Selected game | Tampa Bay Buccaneers vs. Atlanta Falcons

Titans at Commanders (+2.5, 42.5)

Selected game | Washington Commanders vs. Tennessee Titans

49ers at Panthers (+6.5, 39)

Selected game | Carolina Panthers vs. San Francisco 49ers

Eagles at Cardinals (+5, 49)

Selected game | Arizona Cardinals vs. Philadelphia Eagles

Cowboys at Rams (-5.5, 42.5)

Selected game | Los Angeles Rams vs. Dallas Cowboys

Bengals at Ravens (-3, 48.5)

Selected game | Baltimore Ravens vs. Cincinnati Bengals

Monday, Oct. 10

Raiders at Chiefs (-7, 51)

Selected game | Kansas City Chiefs vs. Las Vegas Raiders

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